Attenuated IL-2 muteins leverage the TCR signal to enhance regulatory T cell homeostasis and response in vivo

Interleukin-2 (IL-2), along with T-cell receptor (TCR) signaling, are required to control regulatory T cell (Treg) homeostasis and function in vivo. Due to the heightened sensitivity to IL-2, Tregs retain the ability to respond to low-dose or attenuated forms of IL-2, as currently being developed fo...

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Detalles Bibliográficos
Autores principales: Ma, Shining, So, Michelle, Ghelani, Aazam, Srivas, Rohith, Sahoo, Anupama, Hall, Robyn, Liu, Wenjun, Wu, Hao, Yu, Sherman, Lu, Shiping, Song, Elly, Cariaga, Taryn, Soto, Marcus, Zhou, Hong, Li, Chi-Ming, Chaudhry, Ashutosh, Luo, Xin, Sohn, Sue J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556740/
https://www.ncbi.nlm.nih.gov/pubmed/37809101
http://dx.doi.org/10.3389/fimmu.2023.1257652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10556740/
https://www.ncbi.nlm.nih.gov/pubmed/37809101
http://dx.doi.org/10.3389/fimmu.2023.1257652

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