Cargando…

Improved CAR-T cell activity associated with increased mitochondrial function primed by galactose

CD19 CAR-T cells have led to durable remissions in patients with refractory B-cell malignancies; nevertheless, most patients eventually relapse in the long term. Many interventions aimed at improving current products have been reported, with a subset of them focusing on a direct or indirect link to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gross, Golda, Alkadieri, Suha, Meir, Amilia, Itzhaki, Orit, Aharony-Tevet, Yarden, Yosef, Shahar Ben, Zenab, Angi, Shbiro, Liat, Toren, Amos, Yardeni, Tal, Jacoby, Elad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557609/ https://www.ncbi.nlm.nih.gov/pubmed/37808778 http://dx.doi.org/10.1101/2023.09.23.559091

Ejemplares similares

Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia
por: Rozenbaum, Meir, et al.
Publicado: (2020)

Head-to-head comparison of in-house produced CD19 CAR-T cell in ALL and NHL patients
por: Itzhaki, Orit, et al.
Publicado: (2020)

P520: POINT OF CARE CD19 CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELLS FOR RELAPSED/REFRACTORY ACUTE MYELOID LEUKEMIA (AML) WITH ABERRANT CD19 ANTIGEN EXPRESSION
por: Danylesko, Ivetta, et al.
Publicado: (2023)

Impact of cryopreservation on CAR T production and clinical response
por: Brezinger-Dayan, Karin, et al.
Publicado: (2022)

Molecular and Functional Signatures Associated with CAR T Cell Exhaustion and Impaired Clinical Response in Patients with B Cell Malignancies
por: Beider, Katia, et al.
Publicado: (2022)

Relapse and Resistance to CAR-T Cells and Blinatumomab in Hematologic Malignancies
por: Jacoby, Elad
Publicado: (2019)

Anterior chamber infiltration of CAR T-cells
por: Jacoby, Elad, et al.
Publicado: (2021)

Efficient shallow learning as an alternative to deep learning
por: Meir, Yuval, et al.
Publicado: (2023)

Enhancing the accuracies by performing pooling decisions adjacent to the output layer
por: Meir, Yuval, et al.
Publicado: (2023)

Selective translational control of cellular and viral mRNAs by RPS3 mRNA binding
por: Havkin-Solomon, Tal, et al.
Publicado: (2023)

Mitochondrial augmentation of CD34(+) cells from healthy donors and patients with mitochondrial DNA disorders confers functional benefit
por: Jacoby, Elad, et al.
Publicado: (2021)

Maternal Environmental Contribution to Adult Sensitivity and Resistance to Obesity in Long Evans Rats
por: Schroeder, Mariana, et al.
Publicado: (2010)

Il-6 is non-essential to murine CD19 CAR efficacy, but can mediate acute GVHD following allogeneic BMT with CAR T cell infusion
por: Jacoby, Elad, et al.
Publicado: (2015)

Stimuli-Induced Architectural Transition as a Tool for Controlling the Enzymatic Degradability of Polymeric Micelles
por: Slor, Gadi, et al.
Publicado: (2022)

Tuning the Reactivity of Micellar Nanoreactors by Precise Adjustments of the Amphiphile and Substrate Hydrophobicity
por: Tevet, Shahar, et al.
Publicado: (2021)

Comparison of non-myeloablative lymphodepleting preconditioning regimens in patients undergoing adoptive T cell therapy
por: Nissani, Abraham, et al.
Publicado: (2021)

Evaluating new types of tourniquets by the Israeli Naval special warfare unit
por: Heldenberg, Eitan, et al.
Publicado: (2015)

Mi vida : perfil humano y político de una mujer excepcional
por: Meir, Golda
Publicado: (1978)

Coping with fibromyalgia - a focus group study
por: Hamama, Liat, et al.
Publicado: (2023)

Transcriptional Profiling of Myceliophthora thermophila on Galactose and Metabolic Engineering for Improved Galactose Utilization
por: Wang, Hanyu, et al.
Publicado: (2021)

Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell Malignancies
por: Garcia-Prieto, Carlos A, et al.
Publicado: (2021)

The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders
por: Ferber, Sari Goldstein, et al.
Publicado: (2020)

Quantitative Galactose Colorimetric Competitive Assay Based on Galactose Dehydrogenase and Plasmonic Gold Nanostars
por: Munyayi, Tozivepi Aaron, et al.
Publicado: (2023)

P1108: HIGH COMPLETE RESPONSE RATE FOLLOWING POINT-OF-CARE ANTI CD19 CAR T-CELL THERAPY IN PATIENTS WITH RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA
por: Fried, S., et al.
Publicado: (2022)

THE PREADAPTIVE OXIDATION OF GALACTOSE BY YEAST
por: Reiner, John M., et al.
Publicado: (1947)

Transient hyperglycosylation of rhodopsin with galactose
por: Smith, Sylvia B., et al.
Publicado: (1991)

Reagent-Free Colorimetric Assay for Galactose Using Agarose Gel Entrapping Nanoceria and Galactose Oxidase
por: Nguyen, Phuong Thy, et al.
Publicado: (2020)

Generation of cattle knockout for galactose‐α1,3‐galactose and N‐glycolylneuraminic acid antigens
por: Perota, Andrea, et al.
Publicado: (2019)

Skeletal ligament healing using the recombinant human amelogenin protein
por: Hanhan, Salem, et al.
Publicado: (2016)

The Mechanical Properties Relationship of Radiation-Cured Nanocomposites Based on Acrylates and Cationic Polymerized Epoxies and the Composition of Silane-Modified Tungsten Disulfide Nanoparticles
por: Gercci, Yarden, et al.
Publicado: (2023)

A sustainable working life in the car manufacturing industry: The role of psychosocial factors, gender and occupation
por: Gyllensten, Kristina, et al.
Publicado: (2020)

P889: POINT-OF-CARE ANTI-BCMA CAR T-CELL THERAPY INDUCES ENCOURAGING RESPONSE RATES IN HIGH-RISK RELAPSE/REFRACTORY MULTIPLE MYELOMA
por: Magen, Hila, et al.
Publicado: (2023)

Role and Mechanism of Galactose-Alpha-1,3-Galactose in the Elicitation of Delayed Anaphylactic Reactions to Red Meat
por: Hilger, Christiane, et al.
Publicado: (2019)

Regulation of Cancer Aggressive Features in Melanoma Cells by MicroRNAs
por: Greenberg, Eyal, et al.
Publicado: (2011)

Resistance of Lung Cancer to EGFR-Specific Kinase Inhibitors: Activation of Bypass Pathways and Endogenous Mutators
por: Marrocco, Ilaria, et al.
Publicado: (2023)

Phosphoglucomutase Is Not the Target for Galactose Toxicity in Plants
por: Althammer, Martina, et al.
Publicado: (2020)

Galactose‐modified duocarmycin prodrugs as senolytics
por: Guerrero, Ana, et al.
Publicado: (2020)

Prediction of vaccine hesitancy based on social media traffic among Israeli parents using machine learning strategies
por: Bar-Lev, Shirly, et al.
Publicado: (2021)

Fucose-Galactose Polymers Inhibit Cholera Toxin Binding to Fucosylated Structures and Galactose-Dependent Intoxication of Human Enteroids
por: Cervin, Jakob, et al.
Publicado: (2020)

P1400: THREE YEARS OUTCOMES OF PRIMARY MEDIASTINAL B CELL LYMPHOMA PATIENTS FOLLOWING ANTI CD19 CAR-T CELL THERAPY - A SINGLE CENTER EXPERIENCE
por: Geva, Mika, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_m153cd7i4pcc8fp6qpbe2f4fr3