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Massively parallel identification of sequence motifs triggering ribosome-associated mRNA quality control

Decay of mRNAs can be triggered by ribosome slowdown at stretches of rare codons or positively charged amino acids. However, the full diversity of sequences that trigger co-translational mRNA decay is poorly understood. To comprehensively identify sequence motifs that trigger mRNA decay, we use a ma...

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Detalles Bibliográficos
Autores principales: Chen, Katharine Y., Park, Heungwon, Subramaniam, Arvind Rasi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557687/
https://www.ncbi.nlm.nih.gov/pubmed/37808677
http://dx.doi.org/10.1101/2023.09.27.559793