Short N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4

Highly homologous ubiquitin-binding shuttle proteins UBQLN1, UBQLN2 and UBQLN4 differ in both their specific protein quality control functions and their propensities to localize to stress-induced condensates, cellular aggregates and aggresomes. We previously showed that UBQLN2 phase separates in vit...

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Detalles Bibliográficos
Autores principales: Dao, Thuy P., Rajendran, Anitha, Galagedera, Sarasi K. K., Haws, William, Castañeda, Carlos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557701/
https://www.ncbi.nlm.nih.gov/pubmed/37808720
http://dx.doi.org/10.1101/2023.09.27.559790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557701/
https://www.ncbi.nlm.nih.gov/pubmed/37808720
http://dx.doi.org/10.1101/2023.09.27.559790

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