Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB

The innate immune system features a web of interacting pathways that require exquisite regulation. To identify novel nodes in this immune landscape we conducted a gain of function, genome-wide CRISPR activation screen with influenza A virus. We identified both appreciated and novel antiviral genes,...

Descripción completa

Detalles Bibliográficos
Autores principales: Munir, Moiz, Embry, Aaron, Doench, John G., Heaton, Nicholas S., Wilen, Craig B., Orchard, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557722/
https://www.ncbi.nlm.nih.gov/pubmed/37808733
http://dx.doi.org/10.1101/2023.09.29.560128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557722/
https://www.ncbi.nlm.nih.gov/pubmed/37808733
http://dx.doi.org/10.1101/2023.09.29.560128

Ejemplares similares