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Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB
The innate immune system features a web of interacting pathways that require exquisite regulation. To identify novel nodes in this immune landscape we conducted a gain of function, genome-wide CRISPR activation screen with influenza A virus. We identified both appreciated and novel antiviral genes,...
Autores principales: | Munir, Moiz, Embry, Aaron, Doench, John G., Heaton, Nicholas S., Wilen, Craig B., Orchard, Robert C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557722/ https://www.ncbi.nlm.nih.gov/pubmed/37808733 http://dx.doi.org/10.1101/2023.09.29.560128 |
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