imply: improving cell-type deconvolution accuracy using personalized reference profiles

Real-world clinical samples are often admixtures of signal mosaics from multiple pure cell types. Using computational tools, bulk transcriptomics can be deconvoluted to solve for the abundance of constituent cell types. However, existing deconvolution methods are conditioned on the assumption that t...

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Detalles Bibliográficos
Autores principales: Meng, Guanqun, Pan, Yue, Tang, Wen, Zhang, Lijun, Cui, Ying, Schumacher, Fredrick R., Wang, Ming, Wang, Rui, He, Sijia, Krischer, Jeffrey, Li, Qian, Feng, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557724/
https://www.ncbi.nlm.nih.gov/pubmed/37808714
http://dx.doi.org/10.1101/2023.09.27.559579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10557724/
https://www.ncbi.nlm.nih.gov/pubmed/37808714
http://dx.doi.org/10.1101/2023.09.27.559579

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