Diminishing neuronal acidification by channelrhodopsins with low proton conduction

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Many channelrhodopsins are permeable to protons. We found that in neurons, activation of a high-current channelrhodopsin, CheRiff, led to significant acidification, with faster acidification in the dendrites than in the soma. Experiments with patterned optogenetic stimulation in monolayers of HEK ce...

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Detalles Bibliográficos
Autores principales: Hayward, Rebecca Frank, Brooks, F Phil, Yang, Shang, Gao, Shiqiang, Cohen, Adam E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558203/
https://www.ncbi.nlm.nih.gov/pubmed/37801078
http://dx.doi.org/10.7554/eLife.86833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558203/
https://www.ncbi.nlm.nih.gov/pubmed/37801078
http://dx.doi.org/10.7554/eLife.86833

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