A Theobromine Derivative with Anticancer Properties Targeting VEGFR‐2: Semisynthesis, in silico and in vitro Studies

A computer‐assisted drug design (CADD) approach was utilized to design a new acetamido‐N‐(para‐fluorophenyl)benzamide) derivative of the naturally occurring alkaloid, theobromine, (T‐1‐APFPB), following the pharmacophoric features of VEGFR‐2 inhibitors. The stability and reactivity of T‐1‐AFPB were...

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Detalles Bibliográficos
Autores principales: Eissa, Ibrahim H., Yousef, Reda G., Elkady, Hazem, Elkaeed, Eslam B., Alsfouk, Aisha A., Husein, Dalal Z., Ibrahim, Ibrahim M., Radwan, Mohamed M., Metwaly, Ahmed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558427/
https://www.ncbi.nlm.nih.gov/pubmed/37803417
http://dx.doi.org/10.1002/open.202300066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558427/
https://www.ncbi.nlm.nih.gov/pubmed/37803417
http://dx.doi.org/10.1002/open.202300066

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