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A Theobromine Derivative with Anticancer Properties Targeting VEGFR‐2: Semisynthesis, in silico and in vitro Studies

A computer‐assisted drug design (CADD) approach was utilized to design a new acetamido‐N‐(para‐fluorophenyl)benzamide) derivative of the naturally occurring alkaloid, theobromine, (T‐1‐APFPB), following the pharmacophoric features of VEGFR‐2 inhibitors. The stability and reactivity of T‐1‐AFPB were...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Eissa, Ibrahim H., Yousef, Reda G., Elkady, Hazem, Elkaeed, Eslam B., Alsfouk, Aisha A., Husein, Dalal Z., Ibrahim, Ibrahim M., Radwan, Mohamed M., Metwaly, Ahmed M.
Μορφή: Online Άρθρο Κείμενο
Γλώσσα:English
Έκδοση: John Wiley and Sons Inc. 2023
Θέματα:
Διαθέσιμο Online:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558427/
https://www.ncbi.nlm.nih.gov/pubmed/37803417
http://dx.doi.org/10.1002/open.202300066