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A Theobromine Derivative with Anticancer Properties Targeting VEGFR‐2: Semisynthesis, in silico and in vitro Studies
A computer‐assisted drug design (CADD) approach was utilized to design a new acetamido‐N‐(para‐fluorophenyl)benzamide) derivative of the naturally occurring alkaloid, theobromine, (T‐1‐APFPB), following the pharmacophoric features of VEGFR‐2 inhibitors. The stability and reactivity of T‐1‐AFPB were...
Auteurs principaux: | , , , , , , , , |
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Format: | Online Article Texte |
Langue: | English |
Publié: |
John Wiley and Sons Inc.
2023
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Sujets: | |
Accès en ligne: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558427/ https://www.ncbi.nlm.nih.gov/pubmed/37803417 http://dx.doi.org/10.1002/open.202300066 |