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A Theobromine Derivative with Anticancer Properties Targeting VEGFR‐2: Semisynthesis, in silico and in vitro Studies
A computer‐assisted drug design (CADD) approach was utilized to design a new acetamido‐N‐(para‐fluorophenyl)benzamide) derivative of the naturally occurring alkaloid, theobromine, (T‐1‐APFPB), following the pharmacophoric features of VEGFR‐2 inhibitors. The stability and reactivity of T‐1‐AFPB were...
Главные авторы: | , , , , , , , , |
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Формат: | Online Статья Текст |
Язык: | English |
Опубликовано: |
John Wiley and Sons Inc.
2023
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Предметы: | |
Online-ссылка: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558427/ https://www.ncbi.nlm.nih.gov/pubmed/37803417 http://dx.doi.org/10.1002/open.202300066 |