PI3K/mTOR inhibitors promote G6PD autophagic degradation and exacerbate oxidative stress damage to radiosensitize small cell lung cancer

Our previous study revealed that PI3K/AKT/mTOR signaling was associated with SCLC radioresistance. SBC2 cells were used as primary radioresistance models, while H446 cells were continuously exposed to ionizing radiation (IR) to develop acquired radioresistance. Cell viability and apoptosis assays we...

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Detalles Bibliográficos
Autores principales: Deng, Huan, Chen, Yamei, Wang, Li, Zhang, Yibi, Hang, Qingqing, Li, Peijing, Zhang, Peng, Ji, Jing, Song, Hai, Chen, Ming, Jin, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558571/
https://www.ncbi.nlm.nih.gov/pubmed/37802999
http://dx.doi.org/10.1038/s41419-023-06171-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558571/
https://www.ncbi.nlm.nih.gov/pubmed/37802999
http://dx.doi.org/10.1038/s41419-023-06171-7

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