Comparing the value of mono- vs coculture for high-throughput compound screening in hematological malignancies

Large-scale compound screens are a powerful model system for understanding variability of treatment response and discovering druggable tumor vulnerabilities of hematological malignancies. However, as mostly performed in a monoculture of tumor cells, these assays disregard modulatory effects of the i...

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Detalles Bibliográficos
Autores principales: Herbst, Sophie A., Kim, Vladislav, Roider, Tobias, Schitter, Eva C., Bruch, Peter-Martin, Liebers, Nora, Kolb, Carolin, Knoll, Mareike, Lu, Junyan, Dreger, Peter, Müller-Tidow, Carsten, Zenz, Thorsten, Huber, Wolfgang, Dietrich, Sascha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558604/
https://www.ncbi.nlm.nih.gov/pubmed/37352275
http://dx.doi.org/10.1182/bloodadvances.2022009652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558604/
https://www.ncbi.nlm.nih.gov/pubmed/37352275
http://dx.doi.org/10.1182/bloodadvances.2022009652

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