Cargando…

Pre‐rRNA Facilitates TopBP1‐Mediated DNA Double‐Strand Break Response

In response to genotoxic stress‐induced DNA damage, TopBP1 mediates ATR activation for signaling transduction and DNA damage repair. However, the detailed molecular mechanism remains elusive. Here, using unbiased protein affinity purification and RNA sequencing, it is found that TopBP1 is associated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xin, Di, Gai, Xiaochen, Ma, Yidi, Li, Zexing, Li, Qilin, Yu, Xiaochun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558638/ https://www.ncbi.nlm.nih.gov/pubmed/37582658 http://dx.doi.org/10.1002/advs.202206931

Ejemplares similares

Cdks put Treslin on TopBP1
por: Short, Ben
Publicado: (2011)

Expression of TopBP1 in hereditary breast cancer
por: Forma, Ewa, et al.
Publicado: (2012)

MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks
por: Montales, Katrina, et al.
Publicado: (2022)

High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation
por: Sokka, Miiko, et al.
Publicado: (2015)

Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA
por: Choi, Jun-Hyuk, et al.
Publicado: (2009)

MDC1 collaborates with TopBP1 in DNA replication checkpoint control
por: Wang, Jiadong, et al.
Publicado: (2011)

TopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastases
por: Choi, Seung Ho, et al.
Publicado: (2014)

Emerging roles of the CIP2A–TopBP1 complex in genome integrity
por: Ummethum, Henning, et al.
Publicado: (2023)

TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis
por: Gao, Lei, et al.
Publicado: (2015)

GEMC1 is a TopBP1 interacting protein required for chromosomal DNA replication
por: Balestrini, Alessia, et al.
Publicado: (2010)

Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors
por: Lee, Youngsoo, et al.
Publicado: (2012)

TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability
por: Germann, Susanne M., et al.
Publicado: (2014)

Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy
por: Chowdhury, Pinki, et al.
Publicado: (2014)

TopBP1 Interacts with BLM to Maintain Genome Stability but Is Dispensable for Preventing BLM Degradation
por: Blackford, Andrew N., et al.
Publicado: (2015)

The ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase
por: Sokka, Miiko, et al.
Publicado: (2018)

The Role of DNA Topoisomerase Binding Protein 1 (TopBP1) in Genome Stability in Arabidopsis
por: Parra-Nunez, Pablo, et al.
Publicado: (2021)

An Essential Function for the ATR-Activation-Domain (AAD) of TopBP1 in Mouse Development and Cellular Senescence
por: Zhou, Zhong-Wei, et al.
Publicado: (2013)

Dpb11, the budding yeast homolog of TopBP1, functions with the checkpoint clamp in recombination repair
por: Ogiwara, Hideaki, et al.
Publicado: (2006)

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1
por: Rappas, Mathieu, et al.
Publicado: (2011)

TopBP1 contains transcriptional regulatory domains and regulates gene pathways involved in breast cancer
por: Wright, RHG, et al.
Publicado: (2008)

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1
por: Rappas, Mathieu, et al.
Publicado: (2013)

TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells
por: Pedersen, Rune Troelsgaard, et al.
Publicado: (2015)

CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis
por: Laine, Anni, et al.
Publicado: (2021)

SIRT1 Deacetylates TopBP1 and Modulates Intra-S-Phase Checkpoint and DNA Replication Origin Firing
por: Wang, Rui-Hong, et al.
Publicado: (2014)

TopBP1 contributes to the chemoresistance in non-small cell lung cancer through upregulation of p53
por: Lv, Yinxiang, et al.
Publicado: (2016)

CK2 kinase-mediated PHF8 phosphorylation controls TopBP1 stability to regulate DNA replication
por: Feng, Haihua, et al.
Publicado: (2020)

CK2 kinase-mediated PHF8 phosphorylation controls TopBP1 stability to regulate DNA replication
por: Feng, Haihua, et al.
Publicado: (2021)

The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription
por: Sjøttem, Eva, et al.
Publicado: (2007)

TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks
por: Yan, Shan, et al.
Publicado: (2009)

The Rad4(TopBP1) ATR-Activation Domain Functions in G1/S Phase in a Chromatin-Dependent Manner
por: Lin, Su-Jiun, et al.
Publicado: (2012)

Interaction with TopBP1 Is Required for Human Papillomavirus 16 E2 Plasmid Segregation/Retention Function during Mitosis
por: Prabhakar, Apurva T., et al.
Publicado: (2022)

Acetylation of 53BP1 dictates the DNA double strand break repair pathway
por: Guo, Xiang, et al.
Publicado: (2018)

Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer
por: Liu, Kang, et al.
Publicado: (2021)

Sweet Melody or Jazz? Transcription Around DNA Double-Strand Breaks
por: Long, Qilin, et al.
Publicado: (2021)

Folate deficiency facilitates recruitment of upstream binding factor to hot spots of DNA double-strand breaks of rRNA genes and promotes its transcription
por: Xie, Qiu, et al.
Publicado: (2017)

Tying the loose ends together in DNA double strand break repair with 53BP1
por: Adams, Melissa M, et al.
Publicado: (2006)

Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break
por: Lou, Jieqiong, et al.
Publicado: (2020)

HDGFRP3 interaction with 53BP1 promotes DNA double-strand break repair
por: Zhang, Zhen, et al.
Publicado: (2023)

Rad9, Rad17, TopBP1 and Claspin Play Essential Roles in Heat-Induced Activation of ATR Kinase and Heat Tolerance
por: Tuul, Munkhbold, et al.
Publicado: (2013)

Association between the c.*229C>T polymorphism of the topoisomerase IIβ binding protein 1 (TopBP1) gene and breast cancer
por: Forma, Ewa, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_56048n84hrciopm6q12vets0ik