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Engineering chimeric autoantibody receptor T cells for targeted B cell depletion in multiple sclerosis model: An in-vitro study

BACKGROUND: Recent evidence suggests that B cells and autoantibodies have a substantial role in the pathogenesis of Multiple sclerosis. T cells could be engineered to express chimeric autoantibody receptors (CAARs), which have an epitope of autoantigens in their extracellular domain acting as bait f...

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Detalles Bibliográficos
Autores principales: Sahlolbei, Maryam, Azangou-Khyavy, Mohammadreza, Khanali, Javad, Khorsand, Babak, Shiralipour, Aref, Ahmadbeigi, Naser, Madjd, Zahra, Ghanbarian, Hossein, Ardjmand, Alireza, Hashemi, Seyed Mahmoud, Kiani, Jafar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559048/
https://www.ncbi.nlm.nih.gov/pubmed/37809446
http://dx.doi.org/10.1016/j.heliyon.2023.e19763