Mapping the epigenomic landscape of human monocytes following innate immune activation reveals context-specific mechanisms driving endotoxin tolerance

BACKGROUND: Monocytes are key mediators of innate immunity to infection, undergoing profound and dynamic changes in epigenetic state and immune function which are broadly protective but may be dysregulated in disease. Here, we aimed to advance understanding of epigenetic regulation following innate...

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Detalles Bibliográficos
Autores principales: Amarasinghe, Harindra E., Zhang, Ping, Whalley, Justin P., Allcock, Alice, Migliorini, Gabriele, Brown, Andrew C., Scozzafava, Giuseppe, Knight, Julian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559536/
https://www.ncbi.nlm.nih.gov/pubmed/37805492
http://dx.doi.org/10.1186/s12864-023-09663-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559536/
https://www.ncbi.nlm.nih.gov/pubmed/37805492
http://dx.doi.org/10.1186/s12864-023-09663-0

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