Drosophila CASK regulates brain size and neuronal morphogenesis, providing a genetic model of postnatal microcephaly suitable for drug discovery

BACKGROUND: CASK-related neurodevelopmental disorders are untreatable. Affected children show variable severity, with microcephaly, intellectual disability (ID), and short stature as common features. X-linked human CASK shows dosage sensitivity with haploinsufficiency in females. CASK protein has mu...

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Detalles Bibliográficos
Autores principales: Tello, Judith A., Jiang, Linan, Zohar, Yitshak, Restifo, Linda L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559581/
https://www.ncbi.nlm.nih.gov/pubmed/37805506
http://dx.doi.org/10.1186/s13064-023-00174-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559581/
https://www.ncbi.nlm.nih.gov/pubmed/37805506
http://dx.doi.org/10.1186/s13064-023-00174-y

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