Proteasome inhibition protects blood–brain barrier P-glycoprotein and lowers Aβ brain levels in an Alzheimer’s disease model

BACKGROUND: Loss of P-glycoprotein (P-gp) at the blood–brain barrier contributes to amyloid-β (Aβ) brain accumulation in Alzheimer’s disease (AD). Using transgenic human amyloid precursor protein (hAPP)-overexpressing mice (Tg2576), we previously showed that Aβ triggers P-gp loss by activating the u...

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Detalles Bibliográficos
Autores principales: Vulin, Milica, Zhong, Yu, Maloney, Bryan J., Bauer, Björn, Hartz, Anika M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559617/
https://www.ncbi.nlm.nih.gov/pubmed/37803468
http://dx.doi.org/10.1186/s12987-023-00470-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559617/
https://www.ncbi.nlm.nih.gov/pubmed/37803468
http://dx.doi.org/10.1186/s12987-023-00470-z

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