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Proteasome inhibition protects blood–brain barrier P-glycoprotein and lowers Aβ brain levels in an Alzheimer’s disease model

BACKGROUND: Loss of P-glycoprotein (P-gp) at the blood–brain barrier contributes to amyloid-β (Aβ) brain accumulation in Alzheimer’s disease (AD). Using transgenic human amyloid precursor protein (hAPP)-overexpressing mice (Tg2576), we previously showed that Aβ triggers P-gp loss by activating the u...

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Detalles Bibliográficos
Autores principales:	Vulin, Milica, Zhong, Yu, Maloney, Bryan J., Bauer, Björn, Hartz, Anika M. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559617/ https://www.ncbi.nlm.nih.gov/pubmed/37803468 http://dx.doi.org/10.1186/s12987-023-00470-z

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