High BCR::ABL1 Expression Defines CD34+ Cells with Significant Alterations in Signal Transduction, Short-Proliferative Potential and Self-Renewal Ability

PURPOSE: Chronic Myeloid Leukemia (CML) is a clonal disorder of the hematopoietic stem cell caused by expression of the BCR::ABL1 oncoprotein. High BCR::ABL1 levels have been associated to proliferative advantage of leukemic cells, blast crisis progression and tyrosine kinase inhibitors (TKIs) ineff...

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Detalles Bibliográficos
Autores principales: Massimino, Michele, Stella, Stefania, Tirrò, Elena, Pennisi, Maria Stella, Stagno, Fabio, Vitale, Silvia Rita, Romano, Chiara, Tomarchio, Cristina, Parrinello, Nunziatina Laura, Manzella, Livia, Di Raimondo, Francesco, Vigneri, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559794/
https://www.ncbi.nlm.nih.gov/pubmed/37807980
http://dx.doi.org/10.2147/OTT.S413825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559794/
https://www.ncbi.nlm.nih.gov/pubmed/37807980
http://dx.doi.org/10.2147/OTT.S413825

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