Cargando…

The impact of non-synonymous mutations on miRNA binding sites within the SARS-CoV-2 NSP3 and NSP4 genes

Non-synonymous mutations in the SARS-CoV-2 spike region affect cell entry, tropism, and immune evasion, while frequent synonymous mutations may modify viral fitness. Host microRNAs, a type of non-coding RNA, play a crucial role in the viral life cycle, influencing viral replication and the host immu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rad, S. M. Ali Hosseini, Wannigama, Dhammika Leshan, Hirankarn, Nattiya, McLellan, Alexander D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560223/ https://www.ncbi.nlm.nih.gov/pubmed/37805621 http://dx.doi.org/10.1038/s41598-023-44219-y

Ejemplares similares

Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16
por: Kozielski, Frank, et al.
Publicado: (2021)

Comparison of Binding Site of Remdesivir and Its Metabolites with NSP12-NSP7-NSP8, and NSP3 of SARS CoV-2 Virus and Alternative Potential Drugs for COVID-19 Treatment
por: Jung, Lindsey S, et al.
Publicado: (2020)

Coronavirus NSP6 protein (nsp6)
Publicado: (2014)

Involvement of PRRSV NSP3 and NSP5 in the autophagy process
por: Zhang, Wei, et al.
Publicado: (2019)

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
por: Kirchdoerfer, Robert N., et al.
Publicado: (2019)

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication
por: Wilamowski, Mateusz, et al.
Publicado: (2021)

Identification of novel mutations in the methyltransferase complex (Nsp10-Nsp16) of SARS-CoV-2
por: Azad, Gajendra Kumar
Publicado: (2020)

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
por: Yuen, Chun-Kit, et al.
Publicado: (2020)

Crystallization and diffraction analysis of the SARS coronavirus nsp10–nsp16 complex
por: Debarnot, Claire, et al.
Publicado: (2011)

Immunogenic and antigenic analysis of recombinant NSP1 and NSP11 of PRRS virus
por: Contreras‐Luna, María Josefina, et al.
Publicado: (2022)

Nutrient regulation of lipochitooligosaccharide recognition in plants via NSP1 and NSP2
por: Li, Xin-Ran, et al.
Publicado: (2022)

Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2
por: Peng, Qi, et al.
Publicado: (2020)

Multi-targeting approach for nsp3, nsp9, nsp12 and nsp15 proteins of SARS-CoV-2 by Diosmin as illustrated by molecular docking and molecular dynamics simulation methodologies
por: Kumar, Sumit, et al.
Publicado: (2021)

Mutational analysis of the rotavirus NSP4 enterotoxic domain that binds to caveolin-1
por: Ball, Judith M, et al.
Publicado: (2013)

Effects of Mutagenesis of Murine Hepatitis Virus NSP1 and NSP14 on Replication in Culture
por: Eckerle, Lance D., et al.
Publicado: (2006)

Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 Methyltransferase
por: Benoni, Roberto, et al.
Publicado: (2021)

Scalable Inhibitors of the Nsp3–Nsp4 Coupling in SARS-CoV-2
por: Azizogli, Abdul-Rahman, et al.
Publicado: (2023)

NOD2-dependent BCG-induced trained immunity: A way to regulate innate responses to SARS-CoV2?
por: Wannigama, Dhammika Leshan, et al.
Publicado: (2020)

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites
por: Shannon, Ashleigh, et al.
Publicado: (2020)

Identification and Inhibition of the Druggable Allosteric Site of SARS-CoV-2 NSP10/NSP16 Methyltransferase through Computational Approaches
por: Faisal, Shah, et al.
Publicado: (2022)

The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target
por: Rona, Gergely, et al.
Publicado: (2021)

MicroRNA‐mediated metabolic reprogramming of chimeric antigen receptor T cells
por: Rad, Seyed Mohammad Ali Hosseini, et al.
Publicado: (2022)

Frequent occurrence of mutations in nsp3 and nsp4 of SARS-CoV-2, presumably caused by the inhaled asthma drug ciclesonide
por: Doi, Akihiro, et al.
Publicado: (2022)

Insights into SARS-CoV transcription and replication from the structure of the nsp7–nsp8 hexadecamer
por: Zhai, Yujia, et al.
Publicado: (2005)

Screening of FDA-approved compound library identifies potential small-molecule inhibitors of SARS-CoV-2 non-structural proteins NSP1, NSP4, NSP6 and NSP13: molecular modeling and molecular dynamics studies
por: Sundar, Shobana, et al.
Publicado: (2021)

Exploring the therapeutic nature of limonoids and triterpenoids against SARS-CoV-2 by targeting nsp13, nsp14, and nsp15 through molecular docking and dynamics simulations
por: Vardhan, Seshu, et al.
Publicado: (2021)

Arterivirus nsp2 Cysteine Proteinase
por: Kikkert, Marjolein, et al.
Publicado: (2013)

Coronavirus Inhibitors Targeting nsp16
por: Omer, Ejlal A., et al.
Publicado: (2023)

Predicted coronavirus Nsp5 protease cleavage sites in the human proteome
por: Scott, Benjamin M., et al.
Publicado: (2022)

Chikungunya virus nsP1 interacts directly with nsP2 and modulates its ATPase activity
por: Kumar, Sameer, et al.
Publicado: (2018)

MHV-A59 Orf1a Replicase Protein NSP7-NSP10 Processing in Replication
por: Deming, Damon J., et al.
Publicado: (2006)

The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine
por: Rosas-Lemus, Monica, et al.
Publicado: (2020)

Insertion/deletion hotspots in the Nsp2, Nsp3, S1, and ORF8 genes of SARS-related coronaviruses
por: Akaishi, Tetsuya, et al.
Publicado: (2022)

Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2′-O-methyltransferase activity of nsp10/nsp16 complex
por: Ke, Min, et al.
Publicado: (2012)

Metabolic and Mitochondrial Functioning in Chimeric Antigen Receptor (CAR)—T Cells
por: Rad S. M., Ali Hosseini, et al.
Publicado: (2021)

Targeting the vital non-structural proteins (NSP12, NSP7, NSP8 and NSP3) from SARS-CoV-2 and inhibition of RNA polymerase by natural bioactive compound naringenin as a promising drug candidate against COVID-19
por: Aleebrahim-Dehkordi, Elahe, et al.
Publicado: (2023)

Whole Genome Analysis of African G12P[6] and G12P[8] Rotaviruses Provides Evidence of Porcine-Human Reassortment at NSP2, NSP3, and NSP4
por: Mokoena, Fortunate, et al.
Publicado: (2021)

Mutational Analysis of MHV-A59 Replicase Protein-NSP10
por: Donaldson, Eric F., et al.
Publicado: (2006)

Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics
por: Courouble, Valentine V., et al.
Publicado: (2021)

Activation of the SARS-CoV-2 NSP14 3′–5′ exoribonuclease by NSP10 and response to antiviral inhibitors
por: Riccio, Amanda A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ar4h71c2m127l88nk45h9ca1vp