Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis

Monensin A is a prototypical natural polyether polyketide antibiotic. It acts by binding a metal cation and facilitating its transport across the cell membrane. Biosynthesis of monensin A involves construction of a polyene polyketide backbone, subsequent epoxidation of the alkenes, and, lastly, form...

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Detalles Bibliográficos
Autores principales: Wang, Qian, Liu, Ning, Deng, Yaming, Guan, Yuze, Xiao, Hongli, Nitka, Tara A., Yang, Hui, Yadav, Anju, Vukovic, Lela, Mathews, Irimpan I., Chen, Xi, Kim, Chu-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560226/
https://www.ncbi.nlm.nih.gov/pubmed/37805629
http://dx.doi.org/10.1038/s41467-023-41889-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560226/
https://www.ncbi.nlm.nih.gov/pubmed/37805629
http://dx.doi.org/10.1038/s41467-023-41889-0

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