Zinc chloride-catalyzed cyclizative 1,2-rearrangement enables facile access to morpholinones bearing aza-quaternary carbons

Morpholines and morpholinones are important building blocks in organic synthesis and pharmacophores in medicinal chemistry, however, C3-disubstituted morpholines/morpholinones are extremely difficult to access. Here we show the ZnCl(2)-catalyzed cyclizative 1,2-rearrangement for the efficient synthe...

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Detalles Bibliográficos
Autores principales: Li, Xing-Zi, He, Yu-Ping, Wu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560277/
https://www.ncbi.nlm.nih.gov/pubmed/37805578
http://dx.doi.org/10.1038/s42004-023-01016-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560277/
https://www.ncbi.nlm.nih.gov/pubmed/37805578
http://dx.doi.org/10.1038/s42004-023-01016-y

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