Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas

Hedgehog signaling mediates embryologic development of the central nervous system and other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation. Meningiomas, the most common primary brain tumor, exhibit Hedgehog signaling activation in 6.5% of cases, tri...

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Detalles Bibliográficos
Autores principales: Youngblood, Mark W., Erson-Omay, Zeynep, Li, Chang, Najem, Hinda, Coșkun, Süleyman, Tyrtova, Evgeniya, Montejo, Julio D., Miyagishima, Danielle F., Barak, Tanyeri, Nishimura, Sayoko, Harmancı, Akdes Serin, Clark, Victoria E., Duran, Daniel, Huttner, Anita, Avşar, Timuçin, Bayri, Yasar, Schramm, Johannes, Boetto, Julien, Peyre, Matthieu, Riche, Maximilien, Goldbrunner, Roland, Amankulor, Nduka, Louvi, Angeliki, Bilgüvar, Kaya, Pamir, M. Necmettin, Özduman, Koray, Kilic, Türker, Knight, James R., Simon, Matthias, Horbinski, Craig, Kalamarides, Michel, Timmer, Marco, Heimberger, Amy B., Mishra-Gorur, Ketu, Moliterno, Jennifer, Yasuno, Katsuhito, Günel, Murat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560290/
https://www.ncbi.nlm.nih.gov/pubmed/37805627
http://dx.doi.org/10.1038/s41467-023-41926-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560290/
https://www.ncbi.nlm.nih.gov/pubmed/37805627
http://dx.doi.org/10.1038/s41467-023-41926-y

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