Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nucleases

Accumulation of single stranded DNA (ssDNA) gaps in the nascent strand during DNA replication has been associated with cytotoxicity and hypersensitivity to genotoxic stress, particularly upon inactivation of the BRCA tumor suppressor pathway. However, how ssDNA gaps contribute to genotoxicity is not...

Descripción completa

Detalles Bibliográficos
Autores principales: Hale, Anastasia, Dhoonmoon, Ashna, Straka, Joshua, Nicolae, Claudia M., Moldovan, George-Lucian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560291/
https://www.ncbi.nlm.nih.gov/pubmed/37805499
http://dx.doi.org/10.1038/s41467-023-42011-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560291/
https://www.ncbi.nlm.nih.gov/pubmed/37805499
http://dx.doi.org/10.1038/s41467-023-42011-0

Ejemplares similares