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Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nucleases
Accumulation of single stranded DNA (ssDNA) gaps in the nascent strand during DNA replication has been associated with cytotoxicity and hypersensitivity to genotoxic stress, particularly upon inactivation of the BRCA tumor suppressor pathway. However, how ssDNA gaps contribute to genotoxicity is not...
Autores principales: | Hale, Anastasia, Dhoonmoon, Ashna, Straka, Joshua, Nicolae, Claudia M., Moldovan, George-Lucian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560291/ https://www.ncbi.nlm.nih.gov/pubmed/37805499 http://dx.doi.org/10.1038/s41467-023-42011-0 |
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