Transcription factor-binding k-mer analysis clarifies the cell type dependency of binding specificities and cis-regulatory SNPs in humans

BACKGROUND: Transcription factors (TFs) exhibit heterogeneous DNA-binding specificities in individual cells and whole organisms under natural conditions, and de novo motif discovery usually provides multiple motifs, even from a single chromatin immunoprecipitation-sequencing (ChIP-seq) sample. Despi...

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Detalles Bibliográficos
Autores principales: Tahara, Saeko, Tsuchiya, Takaho, Matsumoto, Hirotaka, Ozaki, Haruka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560430/
https://www.ncbi.nlm.nih.gov/pubmed/37805453
http://dx.doi.org/10.1186/s12864-023-09692-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560430/
https://www.ncbi.nlm.nih.gov/pubmed/37805453
http://dx.doi.org/10.1186/s12864-023-09692-9

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