Metabolic reprogramming induced by DCA enhances cisplatin sensitivity through increasing mitochondrial oxidative stress in cholangiocarcinoma

Background: Cholangiocarcinoma has obvious primary multidrug resistance and is generally resistant to cisplatin and other chemotherapy drugs and high glycolytic levels may be associated with chemotherapy resistance of cholangiocarcinoma cells. Dichloroacetate (DCA) is a specific inhibitor of PDK, wh...

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Detalles Bibliográficos
Autores principales: Qin, Hanjiao, Zheng, Ge, Li, Qiao, Shen, Luyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560739/
https://www.ncbi.nlm.nih.gov/pubmed/37818192
http://dx.doi.org/10.3389/fphar.2023.1128312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560739/
https://www.ncbi.nlm.nih.gov/pubmed/37818192
http://dx.doi.org/10.3389/fphar.2023.1128312

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