Detergent-insoluble PFN1 inoculation expedites disease onset and progression in PFN1 transgenic rats

Accumulating evidence suggests a gain of elusive toxicity in pathogenically mutated PFN1. The prominence of PFN1 aggregates as a pivotal pathological hallmark in PFN1 transgenic rats underscores the crucial involvement of protein aggregation in the initiation and progression of neurodegeneration. De...

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Detalles Bibliográficos
Autores principales: Cui, Shiquan, Zhang, Tingting, Xiong, Xinrui, Zhao, Jihe, Cao, Qilin, Zhou, Hongxia, Xia, Xu-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560758/
https://www.ncbi.nlm.nih.gov/pubmed/37817804
http://dx.doi.org/10.3389/fnins.2023.1279259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560758/
https://www.ncbi.nlm.nih.gov/pubmed/37817804
http://dx.doi.org/10.3389/fnins.2023.1279259

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