A computational model of the DNA damage-induced IKK/ NF-κB pathway reveals a critical dependence on irradiation dose and PARP-1

The activation of IKK/NF-κB by genotoxic stress is a crucial process in the DNA damage response. Due to the anti-apoptotic impact of NF-κB, it can affect cell-fate decisions upon DNA damage and therefore interfere with tumor therapy-induced cell death. Here, we developed a dynamical model describing...

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Detalles Bibliográficos
Autores principales: Konrath, Fabian, Willenbrock, Michael, Busse, Dorothea, Scheidereit, Claus, Wolf, Jana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561052/
https://www.ncbi.nlm.nih.gov/pubmed/37817938
http://dx.doi.org/10.1016/j.isci.2023.107917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561052/
https://www.ncbi.nlm.nih.gov/pubmed/37817938
http://dx.doi.org/10.1016/j.isci.2023.107917

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