W254 in furin functions as a molecular gate promoting anti-viral drug binding: Elucidation of putative drug tunneling and docking by non-equilibrium molecular dynamics

Furins are serine endoproteases that process precursor proteins into their biologically active forms, and they play essential roles in normal metabolism and disease presentation, including promoting expression of bacterial virulence factors and viral pathogenesis. Thus, furins represent vital target...

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Detalles Bibliográficos
Autores principales: Ridgway, Harry, Orbell, John D., Matsoukas, Minos-Timotheos, Kelaidonis, Konstantinos, Moore, Graham J., Tsiodras, Sotiris, Gorgoulis, Vasilis G., Chasapis, Christos T., Apostolopoulos, Vasso, Matsoukas, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561063/
https://www.ncbi.nlm.nih.gov/pubmed/37817778
http://dx.doi.org/10.1016/j.csbj.2023.09.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561063/
https://www.ncbi.nlm.nih.gov/pubmed/37817778
http://dx.doi.org/10.1016/j.csbj.2023.09.003

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