Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo

INTRODUCTION: Natural killer 92 (NK-92) cells are an attractive therapeutic approach as alternative chimeric antigen receptor (CAR) carriers, different from T cells, once they can be used in the allogeneic setting. The modest in vivo outcomes observed with NK-92 cells continue to present hurdles in...

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Detalles Bibliográficos
Autores principales: Silvestre, Renata Nacasaki, Eitler, Jiri, de Azevedo, Julia Teixeira Cottas, Tirapelle, Mariane Cariati, Fantacini, Daianne Maciely Carvalho, de Souza, Lucas Eduardo Botelho, Swiech, Kamilla, Covas, Dimas Tadeu, Calado, Rodrigo T., Montero, Paola Ortiz, Malmegrim, Kelen Cristina Ribeiro, Figueiredo, Marxa L., Tonn, Torsten, Picanço-Castro, Virginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561086/
https://www.ncbi.nlm.nih.gov/pubmed/37818365
http://dx.doi.org/10.3389/fimmu.2023.1226518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561086/
https://www.ncbi.nlm.nih.gov/pubmed/37818365
http://dx.doi.org/10.3389/fimmu.2023.1226518

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