Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult

OBJECTIVE: Mitochondrial pyruvate is a critical intermediary metabolite in gluconeogenesis, lipogenesis, and NADH production. As a result, the mitochondrial pyruvate carrier (MPC) complex has emerged as a promising therapeutic target in metabolic diseases. Clinical trials are currently underway. How...

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Detalles Bibliográficos
Autores principales: Yiew, Nicole K.H., Vazquez, Joel H., Martino, Michael R., Kennon-McGill, Stefanie, Price, Jake R., Allard, Felicia D., Yee, Eric U., Layman, Alexander J., James, Laura P., McCommis, Kyle S., Finck, Brian N., McGill, Mitchell R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561123/
https://www.ncbi.nlm.nih.gov/pubmed/37716594
http://dx.doi.org/10.1016/j.molmet.2023.101808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561123/
https://www.ncbi.nlm.nih.gov/pubmed/37716594
http://dx.doi.org/10.1016/j.molmet.2023.101808

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