Suppressive might of a few: T follicular regulatory cells impede auto-reactivity despite being outnumbered in the germinal centres

The selection of high-affinity B cells and the production of high-affinity antibodies are mediated by T follicular helper cells (Tfhs) within germinal centres (GCs). Therein, somatic hypermutation and selection enhance B cell affinity but risk the emergence of self-reactive B cell clones. Despite be...

Descripción completa

Detalles Bibliográficos
Autores principales: Schips, Marta, Mitra, Tanmay, Bandyopadhyay, Arnab, Meyer-Hermann, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561256/
https://www.ncbi.nlm.nih.gov/pubmed/37818361
http://dx.doi.org/10.3389/fimmu.2023.1253704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561256/
https://www.ncbi.nlm.nih.gov/pubmed/37818361
http://dx.doi.org/10.3389/fimmu.2023.1253704

Ejemplares similares