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Suppressive might of a few: T follicular regulatory cells impede auto-reactivity despite being outnumbered in the germinal centres

The selection of high-affinity B cells and the production of high-affinity antibodies are mediated by T follicular helper cells (Tfhs) within germinal centres (GCs). Therein, somatic hypermutation and selection enhance B cell affinity but risk the emergence of self-reactive B cell clones. Despite be...

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Detalles Bibliográficos
Autores principales:	Schips, Marta, Mitra, Tanmay, Bandyopadhyay, Arnab, Meyer-Hermann, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561256/ https://www.ncbi.nlm.nih.gov/pubmed/37818361 http://dx.doi.org/10.3389/fimmu.2023.1253704

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