Regulatory T-cell deficiency leads to features of autoimmune liver disease overlap syndrome in scurfy mice

INTRODUCTION: Scurfy mice have a complete deficiency of functional regulatory T cells (Treg) due to a frameshift mutation in the Foxp3 gene. The impaired immune homeostasis results in a lethal lymphoproliferative disorder affecting multiple organs, including the liver. The autoimmune pathology in sc...

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Detalles Bibliográficos
Autores principales: Yilmaz, Kaan, Haeberle, Stefanie, Kim, Yong Ook, Fritzler, Marvin J., Weng, Shih-Yen, Goeppert, Benjamin, Raker, Verena K., Steinbrink, Kerstin, Schuppan, Detlef, Enk, Alexander, Hadaschik, Eva N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561387/
https://www.ncbi.nlm.nih.gov/pubmed/37818371
http://dx.doi.org/10.3389/fimmu.2023.1253649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561387/
https://www.ncbi.nlm.nih.gov/pubmed/37818371
http://dx.doi.org/10.3389/fimmu.2023.1253649

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