Regnase-1 downregulation promotes pancreatic cancer through myeloid-derived suppressor cell-mediated evasion of anticancer immunity

BACKGROUND: Pancreatitis is known to be an important risk factor for pancreatic ductal adenocarcinoma (PDAC). However, the exact molecular mechanisms of how inflammation promotes PDAC are still not fully understood. Regnase-1, an endoribonuclease, regulates immune responses by degrading mRNAs of inf...

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Detalles Bibliográficos
Autores principales: Okabe, Junya, Kodama, Takahiro, Sato, Yu, Shigeno, Satoshi, Matsumae, Takayuki, Daiku, Kazuma, Sato, Katsuhiko, Yoshioka, Teppei, Shigekawa, Minoru, Higashiguchi, Masaya, Kobayashi, Shogo, Hikita, Hayato, Tatsumi, Tomohide, Okamoto, Toru, Satoh, Takashi, Eguchi, Hidetoshi, Akira, Shizuo, Takehara, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561497/
https://www.ncbi.nlm.nih.gov/pubmed/37814340
http://dx.doi.org/10.1186/s13046-023-02831-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561497/
https://www.ncbi.nlm.nih.gov/pubmed/37814340
http://dx.doi.org/10.1186/s13046-023-02831-w

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