Cargando…

Cardiac gene therapy treats diabetic cardiomyopathy and lowers blood glucose

Diabetic cardiomyopathy, an increasingly global epidemic and a major cause of heart failure with preserved ejection fraction (HFpEF), is associated with hyperglycemia, insulin resistance, and intracardiomyocyte calcium mishandling. Here we identify that, in db/db mice with type 2 diabetes–induced HF...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jing, Richmond, Bradley, Cluntun, Ahmad A., Bia, Ryan, Walsh, Maureen A., Shaw, Kikuyo, Symons, J. David, Franklin, Sarah, Rutter, Jared, Funai, Katsuhiko, Shaw, Robin M., Hong, TingTing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561727/ https://www.ncbi.nlm.nih.gov/pubmed/37639557 http://dx.doi.org/10.1172/jci.insight.166713

Ejemplares similares

Protective mitochondrial fission induced by stress-responsive protein GJA1-20k
por: Shimura, Daisuke, et al.
Publicado: (2021)

Inhibition of Contraction-Stimulated AMP-Activated Protein Kinase Inhibits Contraction-Stimulated Increases in PAS-TBC1D1 and Glucose Transport Without Altering PAS-AS160 in Rat Skeletal Muscle
por: Funai, Katsuhiko, et al.
Publicado: (2009)

Cardiac T-Tubule cBIN1-Microdomain, a Diagnostic Marker and Therapeutic Target of Heart Failure
por: Li, Jing, et al.
Publicado: (2021)

The Role of PAS Kinase in PASsing the Glucose Signal
por: Grose, Julianne H., et al.
Publicado: (2010)

Effects of Mobile Phone Usage in Supporting Leg Lymphedema Self-care
por: Okutsu, Ayako, et al.
Publicado: (2014)

Exogenous Cardiac Bridging Integrator 1 Benefits Mouse Hearts With Pre-existing Pressure Overload-Induced Heart Failure
por: Li, Jing, et al.
Publicado: (2020)

Pacing-induced Cardiomyopathy
por: Koo, Alex, et al.
Publicado: (2017)

In Mice Subjected to Chronic Stress, Exogenous cBIN1 Preserves Calcium-Handling Machinery and Cardiac Function
por: Liu, Yan, et al.
Publicado: (2020)

SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation
por: Szulik, Marta W., et al.
Publicado: (2023)

Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns
por: Berg, Jordan A., et al.
Publicado: (2023)

An Alternatively Translated Connexin 43 Isoform, GJA1-11k, Localizes to the Nucleus and Can Inhibit Cell Cycle Progression
por: Epifantseva, Irina, et al.
Publicado: (2020)

Chronic cold exposure enhances glucose oxidation in brown adipose tissue
por: Wang, Zhichao, et al.
Publicado: (2020)

Stress Cardiomyopathy Due to Exogenous Thyrotoxicosis From T3 Supplementation
por: Shaw, Kirsten E, et al.
Publicado: (2021)

Cx43 Isoform GJA1-20k Promotes Microtubule Dependent Mitochondrial Transport
por: Fu, Ying, et al.
Publicado: (2017)

Pediatric Patient with a Rash
por: Sutton, Jared, et al.
Publicado: (2014)

Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2–dependent glutaminolysis pathway
por: Wei, Peng, et al.
Publicado: (2022)

Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction
por: Wende, Adam R., et al.
Publicado: (2020)

Dilated cardiomyopathy in childhood
por: Franklin, OM, et al.
Publicado: (2000)

The ESCRT-III pathway facilitates cardiomyocyte release of cBIN1-containing microparticles
por: Xu, Bing, et al.
Publicado: (2017)

My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy
por: Brahma, Manoja K., et al.
Publicado: (2017)

Transthyretin Amyloid Cardiomyopathy Risk Evaluation in a Cohort of Patients With Heart Failure
por: Suh, Angie A, et al.
Publicado: (2023)

Time to Failure on Oral Glucose-Lowering Agents for Patients with Type 2 Diabetes: A Retrospective Cohort Study
por: Boye, Kristina S., et al.
Publicado: (2021)

Rapid reversal of right ventricular pacing–induced cardiomyopathy by His bundle pacing
por: Thosani, Amit J., et al.
Publicado: (2017)

Cinnamon extract lowers glucose, insulin and cholesterol in people with elevated serum glucose
por: Anderson, Richard A., et al.
Publicado: (2015)

Chronic Medication Burden and Complexity for US Patients with Type 2 Diabetes Treated with Glucose-Lowering Agents
por: Boye, Kristina S., et al.
Publicado: (2020)

Sodium–glucose cotransporter 2 inhibitor Dapagliflozin attenuates diabetic cardiomyopathy
por: Arow, M., et al.
Publicado: (2020)

Serum Sestrin2 Was Lower in Septic Shock Patients with Cardiomyopathy
por: Huang, Rongjin, et al.
Publicado: (2022)

Dynasore Protects Mitochondria and Improves Cardiac Lusitropy in Langendorff Perfused Mouse Heart
por: Gao, Danchen, et al.
Publicado: (2013)

Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria
por: Nowinski, Sara M, et al.
Publicado: (2020)

Chronic O-GlcNAcylation and Diabetic Cardiomyopathy: The Bitterness of Glucose
por: Ducheix, Simon, et al.
Publicado: (2018)

A Role of Glucose Overload in Diabetic Cardiomyopathy in Nonhuman Primates
por: Wang, Xiu, et al.
Publicado: (2021)

The Role of Mitochondrial Biogenesis Dysfunction in Diabetic Cardiomyopathy
por: Tao, Li-Chan, et al.
Publicado: (2022)

Decreased Expression of Plakophilin-2 and αT-Catenin in Arrhythmogenic Right Ventricular Cardiomyopathy: Potential Markers for Diagnosis
por: Hung, Pei-Fang, et al.
Publicado: (2022)

Neuropathy, Retinopathy, and Glucose-Lowering Treatments
por: Bloomgarden, Zachary T.
Publicado: (2010)

Pharmacogenetics of novel glucose-lowering drugs
por: Rathmann, Wolfgang, et al.
Publicado: (2021)

Modelling Free-Living and Particle-Associated Bacterial Assemblages across the Deep and Hypoxic Lower St. Lawrence Estuary
por: Cui, Ting Ting, et al.
Publicado: (2020)

Comparative Effectiveness of Anticholinergic Agents for Lower Urinary Tract Symptoms
por: Goodson, Ali B., et al.
Publicado: (2018)

Plants Secondary Metabolites as Blood Glucose-Lowering Molecules
por: Shehadeh, Mayadah Bashir, et al.
Publicado: (2021)

Late gadolinium enhancement does occur in Tako-tsubo cardiomyopathy — A quantitative cardiac magnetic resonance and speckle tracking strain study
por: Gaikwad, Niranjan, et al.
Publicado: (2016)

The rate of glycolysis quantitatively mediates specific histone acetylation sites
por: Cluntun, Ahmad A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_c8o3gb8af8ldk6q636jif39c5p