MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas

Uterine leiomyomas cause heavy menstrual bleeding, anemia, and pregnancy loss in millions of women worldwide. Driver mutations in the transcriptional mediator complex subunit 12 (MED12) gene in uterine myometrial cells initiate 70% of leiomyomas that grow in a progesterone-dependent manner. We showe...

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Detalles Bibliográficos
Autores principales: Zuberi, Azna, Huang, Yongchao, Dotts, Ariel J., Wei, Helen, Coon, John S., Liu, Shimeng, Iizuka, Takashi, Wu, Olivia, Sotos, Olivia, Saini, Priyanka, Chakravarti, Debabrata, Boyer, Thomas G., Dai, Yang, Bulun, Serdar E., Yin, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561729/
https://www.ncbi.nlm.nih.gov/pubmed/37607000
http://dx.doi.org/10.1172/jci.insight.171305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561729/
https://www.ncbi.nlm.nih.gov/pubmed/37607000
http://dx.doi.org/10.1172/jci.insight.171305

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