Cargando…

MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas

Uterine leiomyomas cause heavy menstrual bleeding, anemia, and pregnancy loss in millions of women worldwide. Driver mutations in the transcriptional mediator complex subunit 12 (MED12) gene in uterine myometrial cells initiate 70% of leiomyomas that grow in a progesterone-dependent manner. We showe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zuberi, Azna, Huang, Yongchao, Dotts, Ariel J., Wei, Helen, Coon, John S., Liu, Shimeng, Iizuka, Takashi, Wu, Olivia, Sotos, Olivia, Saini, Priyanka, Chakravarti, Debabrata, Boyer, Thomas G., Dai, Yang, Bulun, Serdar E., Yin, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561729/ https://www.ncbi.nlm.nih.gov/pubmed/37607000 http://dx.doi.org/10.1172/jci.insight.171305

Ejemplares similares

THU625 Med12 Mutation Activates Tryptophan-Kynurenine-ahr Pathway To Promote Growth Of Uterine Leiomyoma
por: Zuberi, Azna, et al.
Publicado: (2023)

Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation
por: Iizuka, Takashi, et al.
Publicado: (2022)

Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status
por: Hutchinson, Anne P., et al.
Publicado: (2022)

THU631 Steroyl-CoA Desaturase Is A Progesterone Receptor Target Gene In Uterine Leiomyoma
por: Komorowski, Allison S, et al.
Publicado: (2023)

Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma
por: Liu, Shimeng, et al.
Publicado: (2018)

Progesterone receptor-DNA methylation crosstalk regulates depletion of uterine leiomyoma stem cells: A potential therapeutic target
por: Liu, Shimeng, et al.
Publicado: (2021)

Targeting DNA Methylation Depletes Uterine Leiomyoma Stem Cell–enriched Population by Stimulating Their Differentiation
por: Liu, Shimeng, et al.
Publicado: (2020)

Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uterine leiomyomas
por: Vidimar, Vania, et al.
Publicado: (2016)

Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas
por: Moyo, Mthabisi B., et al.
Publicado: (2020)

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes
por: Solvay, Marie, et al.
Publicado: (2023)

Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma
por: Xie, Jia, et al.
Publicado: (2018)

Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth
por: Ono, Masanori, et al.
Publicado: (2014)

The tryptophan–kynurenine pathway in immunomodulation and cancer metastasis
por: Basson, Charlise, et al.
Publicado: (2023)

The Role of the Kynurenine/AhR Pathway in Diseases Related to Metabolism and Cancer
por: Shadboorestan, Amir, et al.
Publicado: (2023)

The biological interactions between kynurenine and AhR in melanocytes: in vitro studies
por: Walczak, Katarzyna, et al.
Publicado: (2023)

Role of Stem Cells in Human Uterine Leiomyoma Growth
por: Ono, Masanori, et al.
Publicado: (2012)

Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization
por: Buyukcelebi, Kadir, et al.
Publicado: (2023)

Effect of Tryptophan-Derived AhR Ligands, Kynurenine, Kynurenic Acid and FICZ, on Proliferation, Cell Cycle Regulation and Cell Death of Melanoma Cells—In Vitro Studies
por: Walczak, Katarzyna, et al.
Publicado: (2020)

EHMTI-0189. Tryptophan-kynurenine metabolism in migraine patients
por: Majláth, Z, et al.
Publicado: (2014)

Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects
por: Badawy, Abdulla A-B
Publicado: (2017)

Tryptophan Metabolism in Rat Liver After Administration of Tryptophan, Kynurenine Metabolites, and Kynureninase Inhibitors
por: Badawy, Abdulla A.-B., et al.
Publicado: (2016)

Correction: Oweira et al. Kynurenine Is the Main Metabolite of Tryptophan Degradation by Tryptophan 2,3-Dioxygenase in HepaRG Tumor Cells. J. Clin. Med. 2022, 11, 4794
por: Oweira, Hani, et al.
Publicado: (2023)

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine
por: Campesato, Luis Felipe, et al.
Publicado: (2020)

Nanosensor Detection of an Immunoregulatory Tryptophan Influx/Kynurenine Efflux Cycle
por: Kaper, Thijs, et al.
Publicado: (2007)

Tryptophan-Kynurenine Metabolism and Insulin Resistance in Hepatitis C Patients
por: Oxenkrug, G. F., et al.
Publicado: (2013)

The Role of Tryptophan-Kynurenine in Feather Pecking in Domestic Chicken Lines
por: Birkl, Patrick, et al.
Publicado: (2019)

Kynurenine Pathway of Tryptophan Metabolism in Migraine and Functional Gastrointestinal Disorders
por: Fila, Michal, et al.
Publicado: (2021)

Tryptophan, kynurenine pathway, and diabetic ketoacidosis in type 1 diabetes
por: Hoffman, William H., et al.
Publicado: (2021)

The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites
por: Yeung, Kai Tai Derek, et al.
Publicado: (2022)

New Perspective on Anorexia Nervosa: Tryptophan-Kynurenine Pathway Hypothesis
por: Alberts, Charl, et al.
Publicado: (2023)

Kynurenine Pathway Regulation at Its Critical Junctions with Fluctuation of Tryptophan
por: Newton, Ashley, et al.
Publicado: (2023)

The Tryptophan and Kynurenine Pathway Involved in the Development of Immune-Related Diseases
por: Tsuji, Ai, et al.
Publicado: (2023)

High Kynurenine:Tryptophan Ratio Is Associated With Liver Fibrosis in HIV-Monoinfected and HIV/Hepatitis C Virus–Coinfected Women
por: Kardashian, Ani, et al.
Publicado: (2019)

Tryptophan pyrrolase, kynureninase and kynurenine transaminase activities of human renal tumours.
por: Allegri, G., et al.
Publicado: (1965)

Function of the tryptophan metabolite, L-kynurenine, in human corneal endothelial cells
por: Serbecic, Nermin, et al.
Publicado: (2009)

Tryptophan and kynurenine levels in lenses of Wistar and accelerated-senescence OXYS rats
por: Snytnikova, Olga A., et al.
Publicado: (2009)

Effects of Exhaustive Aerobic Exercise on Tryptophan-Kynurenine Metabolism in Trained Athletes
por: Strasser, Barbara, et al.
Publicado: (2016)

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer
por: Venkateswaran, Niranjan, et al.
Publicado: (2019)

Kynurenine Pathway of Tryptophan Metabolism in Neuropsychiatric Disorders: Pathophysiologic and Therapeutic Considerations
por: Muneer, Ather
Publicado: (2020)

Searching for Peripheral Biomarkers in Neurodegenerative Diseases: The Tryptophan-Kynurenine Metabolic Pathway
por: Török, Nóra, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mdtbpigta29cv2rsohpet3so5c