Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease

Mutation of the ATP2A2 gene encoding sarco-endoplasmic reticulum calcium ATPase 2 (SERCA2) was linked to Darier disease more than 2 decades ago; however, there remain no targeted therapies for this disorder causing recurrent skin blistering and infections. Since Atp2a2-knockout mice do not phenocopy...

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Detalles Bibliográficos
Autores principales: Zaver, Shivam A., Sarkar, Mrinal K., Egolf, Shaun, Zou, Jonathan, Tiwaa, Afua, Capell, Brian C., Gudjonsson, Johann E., Simpson, Cory L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561730/
https://www.ncbi.nlm.nih.gov/pubmed/37561594
http://dx.doi.org/10.1172/jci.insight.170739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561730/
https://www.ncbi.nlm.nih.gov/pubmed/37561594
http://dx.doi.org/10.1172/jci.insight.170739

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