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Loss of Otopetrin 1 affects thermoregulation during fasting in mice

OBJECTIVE: Otopetrin 1 (OTOP1) is a proton channel that is highly expressed in brown adipose tissue. We examined the physiology of Otop1(-/-) mice, which lack functional OTOP1. METHODS: Mice were studied by indirect calorimetry and telemetric ambulatory body temperature monitoring. Mitochondrial fun...

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Detalles Bibliográficos
Autores principales: Tu, Yu-Hsiang, Liu, Naili, Xiao, Cuiying, Gavrilova, Oksana, Reitman, Marc L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561838/
https://www.ncbi.nlm.nih.gov/pubmed/37812612
http://dx.doi.org/10.1371/journal.pone.0292610