Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity

DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden (TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most MMRd tumors do not durably respond to ICB and critical questions remain about immunosurveillance and TMB in these tumors. In t...

Descripción completa

Detalles Bibliográficos
Autores principales: Westcott, Peter M. K., Muyas, Francesc, Hauck, Haley, Smith, Olivia C., Sacks, Nathan J., Ely, Zackery A., Jaeger, Alex M., Rideout, William M., Zhang, Daniel, Bhutkar, Arjun, Beytagh, Mary C., Canner, David A., Jaramillo, Grissel C., Bronson, Roderick T., Naranjo, Santiago, Jin, Abbey, Patten, J. J., Cruz, Amanda M., Shanahan, Sean-Luc, Cortes-Ciriano, Isidro, Jacks, Tyler
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562252/
https://www.ncbi.nlm.nih.gov/pubmed/37709863
http://dx.doi.org/10.1038/s41588-023-01499-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562252/
https://www.ncbi.nlm.nih.gov/pubmed/37709863
http://dx.doi.org/10.1038/s41588-023-01499-4

Ejemplares similares