APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer

The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein implicated in cancer. However, its substrates in cells are not fully delineated. Here APOBEC3B proteomics reveal interactions with a surprising number of R-loop factors. Biochemical experiments show APOBEC3B bindin...

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Detalles Bibliográficos
Autores principales: McCann, Jennifer L., Cristini, Agnese, Law, Emily K., Lee, Seo Yun, Tellier, Michael, Carpenter, Michael A., Beghè, Chiara, Kim, Jae Jin, Sanchez, Anthony, Jarvis, Matthew C., Stefanovska, Bojana, Temiz, Nuri A., Bergstrom, Erik N., Salamango, Daniel J., Brown, Margaret R., Murphy, Shona, Alexandrov, Ludmil B., Miller, Kyle M., Gromak, Natalia, Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562255/
https://www.ncbi.nlm.nih.gov/pubmed/37735199
http://dx.doi.org/10.1038/s41588-023-01504-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562255/
https://www.ncbi.nlm.nih.gov/pubmed/37735199
http://dx.doi.org/10.1038/s41588-023-01504-w

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