Lyophilization process optimization and molecular dynamics simulation of mRNA-LNPs for SARS-CoV-2 vaccine

Some studies have shown that lyophilization significantly improves the stability of mRNA-LNPs and enables long-term storage at 2–8 °C. However, there is little research on the lyophilization process of mRNA-lipid nanoparticles (LNPs). Most previous studies have used empirical lyophilization with onl...

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Detalles Bibliográficos
Autores principales: Li, Mingyuan, Jia, Lin, Xie, Yanbo, Ma, Wenlin, Yan, Zhihong, Liu, Fufeng, Deng, Jie, Zhu, Ali, Siwei, Xue, Su, Wen, Liu, Xiaofeng, Li, Shiqin, Wang, Haomeng, Yu, Peng, Zhu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562438/
https://www.ncbi.nlm.nih.gov/pubmed/37813912
http://dx.doi.org/10.1038/s41541-023-00732-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562438/
https://www.ncbi.nlm.nih.gov/pubmed/37813912
http://dx.doi.org/10.1038/s41541-023-00732-9

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