Deep mutational scanning reveals the molecular determinants of RNA polymerase-mediated adaptation and tradeoffs

RNA polymerase (RNAP) is emblematic of complex biological systems that control multiple traits involving trade-offs such as growth versus maintenance. Laboratory evolution has revealed that mutations in RNAP subunits, including RpoB, are frequently selected. However, we lack a systems view of how mu...

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Detalles Bibliográficos
Autores principales: Choudhury, Alaksh, Gachet, Benoit, Dixit, Zoya, Faure, Roland, Gill, Ryan T., Tenaillon, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562459/
https://www.ncbi.nlm.nih.gov/pubmed/37813857
http://dx.doi.org/10.1038/s41467-023-41882-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562459/
https://www.ncbi.nlm.nih.gov/pubmed/37813857
http://dx.doi.org/10.1038/s41467-023-41882-7

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