Overexpression of FTO inhibits excessive proliferation and promotes the apoptosis of human glomerular mesangial cells by alleviating FOXO6 m6A modification via YTHDF3-dependent mechanisms

Background: N6-methyladenosine (m6A) is a prevalent post-transcriptional modification presented in messenger RNA (mRNA) of eukaryotic organisms. Chronic glomerulonephritis (CGN) is characterised by excessive proliferation and insufficient apoptosis of human glomerular mesangial cells (HGMCs) but its...

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Detalles Bibliográficos
Autores principales: Zhuang, Xingxing, Liu, Tao, Wei, Liangbing, Gao, Jiarong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562590/
https://www.ncbi.nlm.nih.gov/pubmed/37822879
http://dx.doi.org/10.3389/fphar.2023.1260300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562590/
https://www.ncbi.nlm.nih.gov/pubmed/37822879
http://dx.doi.org/10.3389/fphar.2023.1260300

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