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Thyroxine metabolite-derived 3-iodothyronamine (T1AM) and synthetic analogs as efficient suppressors of transthyretin amyloidosis

Aggregation and fibrillization of transthyretin (TTR) is a fatal pathogenic process that can cause cardiomyopathic and polyneuropathic diseases in humans. Although several therapeutic strategies have been designed to prevent and treat related pathological events, there is still an urgent need to dev...

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Detalles Bibliográficos
Autores principales: Kim, Bokyung, Ko, Young Ho, Si, Jinbeom, Na, Jongbum, Ortore, Gabriella, Chiellini, Grazia, Kim, Jin Hae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562617/
https://www.ncbi.nlm.nih.gov/pubmed/37822560
http://dx.doi.org/10.1016/j.csbj.2023.09.028