Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila

Huntington’s disease (HD) is a neurodegenerative disease characterized by movement and cognitive dysfunction. HD is caused by a CAG expansion in exon 1 of the HTT gene that leads to a polyglutamine (PQ) repeat in the huntingtin protein, which aggregates in the brain and periphery. Previously, we use...

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Detalles Bibliográficos
Autores principales: Roth, Jonathan R., de Moraes, Ruan Carlos Macedo, Xu, Brittney P., Crawley, Savannah R., Khan, Malghalara A., Melkani, Girish C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562706/
https://www.ncbi.nlm.nih.gov/pubmed/37823007
http://dx.doi.org/10.3389/fnagi.2023.1223911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562706/
https://www.ncbi.nlm.nih.gov/pubmed/37823007
http://dx.doi.org/10.3389/fnagi.2023.1223911

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